Treatment of Bone and Joint Diseases with Gancao Fuzitang： A Review / 中国实验方剂学杂志

Gancao Fuzitang originates from the Treatise on Febrile Diseases and Miscellaneous Diseases （《伤寒杂病论》） and is mainly used to treat pain in the bones and joints and symptoms such as no flexion or extension. It has the effect of tonifying the spleen and kidney and removing dampness and turbidity， so it is widely used in the clinical treatment of various bone and joint diseases. This article reviewed the clinical research and mechanism of Gancao Fuzitang in the treatment of bone and joint diseases. The research has found that this prescription has good efficacy in treating bone and joint diseases such as rheumatoid arthritis， rheumatoid arthritis， ankylosing spondylitis， gout， and intervertebral disc herniation. Its mechanism of action may be related to regulating the level of inflammatory factors， antioxidation， and the protein expression of inflammatory and apoptotic cell-related pathways， improving bone and joint diseases， and alleviating related symptoms. This study can provide a reference for further deepening the research on the prevention and treatment of bone and joint diseases with Gancao Fuzitang.

Varmam Therapy for Common Shoulder Joint Pathological Conditions- A Review

Varmam- a discrete medical science and a great contribution of Siddhars to Tamil Nadu. It encompases Varma martial arts, Varma therapy, internal and external medicines. Varma therapy and medicines effectively treat neuro musculoskeletal conditions which is admirable. Shoulder pain is most common orthopaedic condition. It is the third common cause of musculoskeletal consultations in primary care. Approximately 1% of adult develops new shoulder pain annually. Common pathological conditions of shoulder like rotator cuff disorders and adhesive capsulitis etc exhibits similar clinical features like pain and stiffness of shoulder joint and restricted movements. Varma therapy rearranges and regulates the “Vaasi” and consequently helps to maintain the equilibrium of trihumours (Vatham, Pitham, Kapham). This review article explicates the Varma points for the treatment of shoulder pathological conditions, the exact anatomical location of Varma points and the appropriate method of its manipulation, certainly a key to further research articles.

Nuevas estrategias tecnológicas para la administración de fármacos en el tratamiento de patologías articulares

Despite the availability of drugs and pharmaceutical forms for the treatment of rheumatoid arthritis and osteoarthritis symptoms, their adverse effects and lack of response to therapy reinforces the need to search for new technological formulation strategies capable of delaying the progress of the disease, with better therapeutic results and prolonged control of arthropathy. The aim of this bibliographic review was to identify new reported therapeutic approaches for these diseases. The treatment of rheumatoid arthritis and osteoarthritis is an unresolved challenge, due to the complexity of these diseases. Thus, the new therapies aim to suppress inflammatory mediators and to reduce the degradation of the extracellular matrix. In addition, the use of nano and microtechnology takes advantage of the properties of polymers, lipids, peptides, and nucleic acids to develop controlled drug release systems, aiming to obtain highly effective precision therapies, whose usefulness should be evaluated in future clinical trials.

Sports yoga based on the prevention of joint injuries / Ioga esportiva baseada na prevenção de lesões articulares / Yoga deportivo basado en la prevención de lesiones articulares

ABSTRACT Introduction During sports, the athletes' joints bear a strong overload, causing joint injuries, which have a strong impact on the sports level and shorten the sports athletes' careers. Objective Explore the preventive effect of yoga practice on joint injuries. Methods In this study, an experimental protocol was tested. The experimental group adopted the yoga teaching method, and the control group adopted traditional massage. The interventions were performed three times a week, lasting one hour for a total of 6 months. The scores of the VAS and the Oswestry functional disorder index questionnaire were collected and compared, and the joint activity before and after the experiment was also collected and analyzed. Results Both methods can effectively improve the overall joint condition and prevent joint injury, but the effect of the yoga teaching group was superior to the massage group. Conclusion Compared to traditional massage, sport-oriented yoga training proved superior, better adapted to the actual situation of athletes, and more cost-effective. Further studies are recommended for its promotion. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.

RESUMO Introdução Durante os esportes, as articulações dos atletas suportam uma forte sobrecarga, ocasionando lesões articulares, ocasionando um forte impacto no nível esportivo e abreviando a carreira dos atletas esportivos. Objetivo Explorar o efeito preventivo da prática de ioga sobre as lesões articulares. Métodos Neste trabalho, foi testado um protocolo experimental. O grupo experimental adotou o método de ensino de ioga, e o grupo de controle adotou a massagem tradicional. As intervenções foram realizadas três vezes por semana, com duração de uma hora num total de 6 meses. As pontuações do VAS e do questionário do índice de desordem funcional Oswestry foram coletadas e comparadas, e a atividade conjunta antes e depois do experimento também foi coletada e analisada. Resultados Ambos os métodos podem efetivamente melhorar a condição articular geral e prevenir lesões articulares, porém o efeito do grupo de ensino de ioga demonstrou-se superior ao grupo de massagem. Conclusão Em comparação com a massagem tradicional, o treinamento de ioga voltado para o esporte demonstrou-se superior, adaptando-se melhor à situação real dos atletas, além de ser mais econômico. Recomenda-se maiores estudos para a sua promoção. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento.

RESUMEN Introducción Durante la práctica deportiva, las articulaciones de los atletas soportan una fuerte sobrecarga, provocando lesiones articulares, causando un fuerte impacto en el nivel deportivo y acortando la carrera deportiva de los atletas. Objetivo Explorar el efecto preventivo de la práctica del yoga en las lesiones articulares. Métodos En este trabajo se ha probado un protocolo experimental. El grupo experimental adoptó el método de enseñanza del yoga, y el grupo de control adoptó el masaje tradicional. Las intervenciones se realizaron tres veces por semana, con una duración de una hora, durante un total de 6 meses. Se recogieron y compararon las puntuaciones del VAS y del cuestionario del índice de trastornos funcionales de Oswestry, y también se recogió y analizó la actividad articular antes y después del experimento. Resultados Ambos métodos pueden mejorar eficazmente el estado general de las articulaciones y prevenir las lesiones articulares, pero el efecto del grupo de enseñanza de yoga demostró ser superior al del grupo de masaje. Conclusión En comparación con el masaje tradicional, el entrenamiento de yoga orientado al deporte demostró ser superior, adaptándose mejor a la situación real de los atletas, además de ser más rentable. Se recomienda realizar más estudios para su promoción. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento.

Role of NLRP3 Inflammasome in Bone and Joint Diseases and Traditional Chinese Medicine Intervention： A Review / 中国实验方剂学杂志

Nucleotide binding oligomeric dome-like receptor protein 3 （NLRP3） inflammasome is an intracellular sensing protein complex， and it is an important player in the innate immune system， capable of sensing foreign pathogens and endogenous danger signals. After tissue injury， the activation of the NLRP3 inflammasome induces the release of the pro-inflammatory cytokines interleukin （IL）-1β and IL-18， while promoting gasdermin D-mediated pyroptosis. Existing studies have shown that NLRP3 inflammasome plays a key role in the occurrence and development of common bone and joint diseases such as osteoporosis， osteoarthritis， rheumatoid arthritis， and gouty arthritis by inducing inflammatory cascade reaction and accelerating bone resorption and cartilage destruction. Therefore， blocking the NLRP3 inflammasome signaling pathway may be an effective strategy to treat or prevent bone and joint diseases. Currently， researchers have developed and tested several drugs that selectively target the NLRP3 inflammasome in animal and clinical studies， but the progress has been poor due to obvious side effects and high prices. Traditional Chinese medicine （TCM） has been widely recognized in the treatment of bone and joint diseases due to its unique advantages of multi-target， multi-pathway， multi-mechanism synergism， low price， and low side effects. With the deepening of research， the targeted intervention of NLRP3 inflammasome by TCM in the treatment of bone and joint diseases has attracted wide attention. In this paper， the mechanism of NLRP3 inflammasome in osteoarthritis was summarized by analyzing relevant literature in China and abroad in recent years， and the progress of targeted intervention of NLRP3 inflammasome by TCM in the treatment of bone and joint diseases was systematically reviewed， so as to provide new ideas and theoretical basis for the treatment of bone and joint diseases.

A study on certolizumab pegol in the treatment of inflammatory joint diseases of women of childbearing age / 中华风湿病学杂志

Objective:To evaluate the efficacy of certolizumab pegol (CZP) in the treatment of Chinese women of childbearing age with inflammatory joint diseases and the effect of intrauterine exposure on infant vaccination and risk of infection.Methods:This study is a retrospective observation study, including female patients of childbearing age who were treated with CZP in the outpatient clinic from November 2019 to October 2020. The patients were followed up for 24 weeks, and the related data was collected. We adopted disease activity score-28 for rheumatoid arthritis with CRP (DAS28-CRP), clinical disease activity index (CDAI) and simplified disease activity index (SDAI) to evaluate disease activity. Bath ankylosing spon-dylitis disease activity index (BASDAI) and ankylosing spondylitis disease activity score (ASDAS-ESR) were used to assess the disease activity of patients with ankylosing spondylitis or spondyloarthritis (AS/SpA). Low disease activity (LDA), the dosage of glucocorticoid (GC) and the qualified rates of ACR20 and ASAS20 were calculated to validate the efficacy of CZP. The data of infants vaccination and infection was recorded to estimate the effect of intrauterine exposure on infants. Correlation analysis were performed using paired t test or Mann Whitney test. All statistical tests were bilateral, with a significance of P<0.05. Results:Twenty women entered the study and fifteen completed, including eight patients with RA, six patients with AS and 1 patient with SpA. The average age was (30±5) years and the median symptom duration was 5.0 (3.0, 6.5) years. When these RA patients were enrolled into the study, DAS28-CRP, CDAI and SDAI were (3.4±1.2), 15.5(9.5, 21.0) and (18±12) respectively; and after the use of CZP, the DAS28-CRP, CDAI and SDAI changed to (2.5±0.9)( t=2.48, P=0.042), 4.5(3.5, 10.8) ( U=12.50, P=0.040) and (9±6) (t=2.76, P=0.028). At the first follow-up, the ACR20 rate was 50%. and at the end of the study, the LDA rate was 75%(6/8), three(37.5%) women reduced the dosage of GC. Among the AS/SpA patients, BASDAI was 19.0(14.5, 26.0) and ASDAS-ESR was (2.4±1.0) at first, while after treatment, BASDAI turned into 9.0(1.0, 10.5) ( U=11.50, P=0.100) and ASDAS-ESR turned into (1.4±0.5) ( t=3.44, P=0.014). The ASAS20 rate at the first follow-up was 71.4%(5/7), and 85.7%(6/7) at the end of the study. Four patients experienced adverse events, resulting in drug withdrawal. Three women were pregnant when they were enrolled into the study, and three others became pregnant during the research. Six infants were vaccinated with live attenuated vaccines and inactivated vaccines according to the plan. No adverse event related to vaccination was reported, but one of the babies had perianal abscess and the other one had cold symptoms, while both improved after treatment. Conclusion:CZP can effectively control disease activity of women with inflammatory joint diseases during pregnancy, and intrauterine exposure is safe to infants during the study period.

Prevalence of osteoarthrosis and its association with hot spring bathing among local adults in typical hot spring areas of Guizhou Province / 上海预防医学

Objective To investigate the prevalence of osteoarthrosis and the association between hot spring bathing and osteoarthrosis among local adults in typical hot spring areas of Guizhou Province. Methods A face-to-face questionnaire survey was conducted among residents aged from 30 to 65 in five typical hot spring areas, including Xifeng(Xifeng County, Guiyang), Jianhe(Jianhe County, Qiandongnan), Fodingshan(Shiqian County, Tongren), Guiyu(Wudang District, Guiyang)and Huishangu(Suiyang County, Zunyi). Residents' basic information, bone and joint diseases prevalence, hot spring bathing, and other health-related behaviors were investigated in this study. The prevalence of local bone and joint diseases was analyzed, and binary logistic regression was used to calculate OR(95%CI)to analyze the association between hot spring bathing and bone and joint diseases. Results A total of 3 708 adults(1 648 males and 2 060 females)were included as the statistical analysis survey subjects, and 794 people reported bone and joint diseases, accounting for a prevalence rate of 21.41%, 95% CI: 0.201-0.227. The prevalence of females(24.56%)was higher than that of males(17.48%)(P < 0.001). The prevalence rates of diseases increased with age(χtrend2=130.265, P < 0.001). There were also statistically significant differences in the prevalence rate of bone and joint diseases among different genders, age groups, occupations, education levels, and smoking behaviors(P < 0.05). After gender, age, occupation, education and smoking were adjusted for, compared with the group who never took hot spring baths, participants who took hot spring baths occasionally(OR=0.793, 95%CI: 0.631-0.996)and frequently(OR=0.713, 95%CI: 0.536-0.948)were associated with a lower risk of bone and joint diseases. Conclusion The prevalence of osteoarthrosis is 21.41% in the typical hot spring areas of Guizhou Province. Older or females have a higher risk of prevalence of bone and joint diseases. Hot spring bathing may be associated with a lower risk of bone and joint diseases.

Cost analysis of hemophilia treatment in a Brazilian public blood center / Custo-análise do tratamento da hemofilia em um hemocentro público brasileiro

Abstract Background hemophilia is a rare coagulopathy, treated by replacing the missing blood clotting factor. Objective to assess the direct costs of hemophilia treatment from the perspective of the Unified Health System, highlighting the impact costs of new therapeutic modalities. Method partial economic assessment of the direct costs of hemophilia, in which were collected data from patient records from 2011 to 2015, at the Blood Center in the city of Juiz de Fora. Costs were assigned to consultations, exams, hospitalizations, and medications according to the price list of the National Health Surveillance Agency (in Portuguese ANVISA) and the Table of Procedures, and Medications. Results among 98 patients evaluated, 76 had hemophilia A, and 43.3% presented severe hemophilia. The number of consultations and the consumption of Clotting Factor Concentrates (CFCs) were higher in severe hemophilia. Hospitalizations were rare. Direct costs increased 286.8% from 2011 to 2015. The mean annual cost per patient was R$57,416.43, with no significant difference between hemophilia A and B. The expenditures for factor concentrates amounted to 99.46% of total costs. The actual impact cost was more than R$6,000,000.00. Conclusion the direct costs of hemophilia were high, mainly due to factor concentrates. There was an increase in costs with the incorporation of technologies, although there are some areas with potential inefficiencies.

Resumo Introdução hemofilia é uma coagulopatia rara, tratada com reposição do fator de coagulação deficiente. Objetivo avaliar custos diretos do tratamento da hemofilia pela perspectiva do Sistema Único de Saúde brasileiro, destacando o impacto nos custos das novas modalidades terapêuticas. Método análise econômica parcial dos custos diretos da hemofilia. Foram coletados dados de prontuários de pacientes do Hemocentro de Juiz de Fora de 2011-2015. Aos atendimentos, exames, hospitalizações e medicamentos, foram atribuídos custos conforme as Tabelas de Preços da Agência de Vigilância Sanitária e de Procedimentos e Medicamentos do SUS. Resultados entre 98 pacientes avaliados, 76 tinham hemofilia A e 43,3%, hemofilia grave. O número de consultas e o consumo de concentrados de fatores da coagulação foram mais altos na hemofilia grave. Hospitalizações foram raras. Os custos diretos aumentaram 286,8% entre 2011-2015. O custo anual médio por paciente foi R$57.416,43 sem diferença significativa entre hemofilia A e B. Os concentrados de fator corresponderam a 99,46% dos custos totais. O impacto nos custos foi de mais de R$6.000.000,00. Conclusão custos diretos da hemofilia são altos, principalmente devido aos concentrados de fator. O aumento nos custos com as novas tecnologias foi muito elevado embora ainda haja áreas com ineficiências no tratamento da hemofilia.

Pre-planning ankle arthrodesis using 3d reconstructed tomographies / Desenvolvimento da artrodese do tornozelo baseada na tomografia com reconstrução 3d

ABSTRACT Objective: To implement one analysis method of the ankle bone contour that could make a more precise ankle arthrodesis. Methods: Twenty tomographies were submitted to 3D reconstruction. Seven points of anatomic interest for ankle arthrodesis with the three screws technique were marked with a triplannar marker. The median of the position of markers was estimated, and the union of the seven median points allow the construction of one median ankle for that population. Using this median ankle, sizes and angles for the screws position were determined. Results: Two median ankles were reconstructed, left and right. The position of the screw passage were determined considering the anatomical parameters. In the right ankle the lateral to medial screw should enter 4.56 cm and 0.79 above and posterior to lateral malleolus, with one inclination of 17.34° in relation to tibial longitudinal axis; and 0° in relation to tibial axial plane. The position for the other two screws is also described. Conclusion: Our article is the first to presents one precise guide for ankle arthrodesis based on a populational assessment. Level of evidence II, Diagnostic Studies.

RESUMO Objetivo: Implementar método de análise do contorno e alinhamento ósseos no tornozelo de uma população normal, possibilitando uma artrodese tibiotársica mais precisa. Métodos: Tomografias de vinte tornozelos foram submetidas à reconstrução 3D. Nesses exames, 7 pontos anatômicos de interesse para a técnica de fixação com 3 parafusos foram identificados e marcados com indicadores da posição triplanar. As médias das localizações de cada ponto foram calculadas. A união dessas médias permitiu a reconstrução de um tornozelo padrão daquela população. Nesses tornozelos médios estudou-se os comprimentos e ângulos para a passagem dos parafusos. Resultados: Dois tornozelos, direito e esquerdo, foram reconstruídos. A posição para a passagem dos parafusos em relação a parâmetros anatômicos foi determinada. Para o tornozelo direito, a passagem do parafuso de lateral para medial deve ocorrer com o ponto de entrada 4,56 cm acima e 0,79 cm posterior à ponta do maléolo lateral, com inclinação de 17,34° em relação ao eixo longitudinal e 0° em relação ao eixo axial da tíbia. As posições dos outros dois parafusos também estão descritas. Conclusão: Esse é o primeiro trabalho que apresenta um guia preciso para realização da artrodese do tornozelo, baseado em um estudo populacional. Nível de evidência II, Estudos Diagnósticos.

Os benefícios da laserterapia de baixa intensidade associados a exercícios domiciliares em idosos com osteoartrite de joelho / The benefits of low-intensity laser therapy associated with home exercises in elderly knee osteoarthritis

INTRODUÇÃO: A Osteoartrite (OA) é uma doença musculoesquelética com predomínio na população idosa. O tratamento com Laserterapia tem sido um dos métodos seguros e não invasivos para o tratamento da OA. OBJETIVO: Observar a influência na dor, rigidez e função em idosos antes e depois da aplicação da laserterapia associados a exercícios domiciliares. MÉTODOS: Dez pacientes idosos com OA de joelho, submetidos a 12 sessões de Laserterapia, 3 vezes por semana e orientados a realizarem exercícios domiciliares durante o período do estudo. Foi utilizado o Laser de baixa potência Class 3B Chattanooga, com energia total de 36J (divididos em 6 pontos- 6J por ponto) conforme a dosagem da World Association of Laser Therapy (WALT). Para mensuração do quadro álgico foi utilizados a Escala Visual Analógica (EVA); Índice de Osteoartrite de Western Ontario (WOMAC) e Índice de Lequesne para dor, rigidez e funcionalidade. Os exercícios domiciliares foram explicados e demonstrados pelo avaliador e orientado a realizar 3 vezes por semana durante 12 sessões. RESULTADOS: Observamos que após aplicações de Laserterapia e exercícios domiciliares, não houve melhora na EVA, porém com melhora significativa nos quesitos WOMAC geral (p=0,01) e função (p=0,001) enquanto os demais não houve significância (p>0,5) quando avaliados por meio do t-test, já na comparação entre questionários houve correlação forte em WOMAC e LEQUESNE com a Correlação de Pearson. CONCLUSÃO: Pode-se concluir que a Laserterapia associada a exercícios domiciliares não evidencia melhora significativa do quadro álgico através da EVA, podendo ser uma resposta subjetiva com dificuldade de compreensão pelos pacientes, porém foi observado melhora significativa na evolução funcional do paciente medidas pelos questionários WOMAC e LEQUESNE nos pacientes com OA de joelho.

INTRODUCTION: Osteoarthritis (OA) is a musculoskeletal disease with predominance in the elderly population. Laser therapy has been one of the safe and non-invasive methods for treating OA. OBJECTIVE: To observe the influence on pain, stiffness and function in the elderly before and after the application of home exercise laser therapy. METHODS: Ten elderly patients with knee OA who underwent 12 laser therapy sessions 3 times a week. The Chattanooga Class 3B Low Power Laser was used, with a total energy of 36J (divided into 6 points - 6J per point) according to the dosage of the World Association of Laser Therapy (WALT). We used the Visual Analog Scale (VAS) for pain; Western Ontario Osteoarthritis Index (WOMAC) and Lequesne Index for pain, stiffness and functionality. Home exercises were explained and demonstrated by the evaluator and instructed to perform 3 times a week during 12 sessions. RESULTS: We observed that after laser therapy and home exercises, there was no improvement in VAS but there was significant improvement in the general WOMAC (p = 0.01) and function (p = 0.001), while the others were not significant (p> 0, 5), when compared to the t-test, when compared to the Pearson correlation, there was an improvement in the WOMAC and LEQUESNE questionnaires. CONCLUSION: It can be concluded that after applying home exercise laser therapy, there was no significant improvement in pain through VAS, which may be a subjective response with difficulty for patients to understand, but there was a significant improvement in the patient's functional evolution measured by the questionnaires. WOMAC and LEQUESNE in patients with knee OA.

Biomechanical comparison of plantar-to-dorsal and dorsal-to-plantar screw fixation strength for subtalar arthrodesis / Comparação biomecânica da força de fixação de parafuso com orientação de plantar para dorsal e vice-versa para artrodese subtalar

ABSTRACT Objective To compare screw fixation strength for subtalar arthrodesis. Methods Eight matched pairs of cadaver feet underwent subtalar joint arthrodesis with two 7.3mm cannulated screws. Randomization was used to assign screw orientation, such that one foot in each pair was assigned dorsal to plantar screw orientation (DP Group), and the other foot, plantar to dorsal orientation (PD Group). Standard surgical technique with fluoroscopy was used for each approach. Following fixation, each specimen was loaded to failure with a Bionix ® 858 MTS device, applying a downward axial force at a distance to create torque. Torque to failure was compared between DP and PD Groups using Student's t test, with p=0.05 used to determine statistical significance. Results Statistical analysis demonstrated that the mean torque to failure slightly favored the DP Group (37.3Nm) to the PD Group (32.2Nm). However, the difference between the two groups was not statistically significant (p=0.55). Conclusion In subtalar arthrodesis, there is no significant difference in construct strength between dorsal-to-plantar and plantar-to-dorsal screw orientation. The approach chosen by the surgeon should be based on factors other than the biomechanical strength of the screw orientation.

RESUMO Objetivo Comparar a força de fixação dos parafusos para artrodese subtalar. Métodos Oito pares de pés de cadáveres frescos foram submetidos à artrodese da articulação subtalar com dois parafusos canulados de 7,3mm. A randomização foi usada para atribuir a orientação do parafuso, de modo que um pé em cada par foi designado com orientação de dorsal para plantar (Grupo DP), e o outro pé com orientação de plantar para dorsal (Grupo PD). Técnica cirúrgica padrão com radioscopia foi usada para os procedimentos. Após a fixação, cada amostra foi testada até a falha com um dispositivo Bionix®858 MTS, aplicando força axial descendente a uma distância para criar torque. O torque de falha foi comparado entre os Grupos DP e PD, usando o teste t de Student, com p=0,05 usado para determinar significância estatística. Resultados A análise estatística demonstrou que a média do torque até a falha favoreceu ligeiramente o Grupo DP (37,3Nm) em relação ao PD (32,2Nm). No entanto, a diferença entre os dois grupos não foi estatisticamente significativa (p=0,55). Conclusão Na artrodese subtalar, não há diferença significativa na força de compressão entre as orientações dos parafusos dorsal-plantar e plantar-dorsal. A abordagem escolhida pelo cirurgião deve ser baseada em outros fatores, sem preocupação com a força biomecânica da orientação dos parafusos.

T1ρ technique in quantitatively evaluation on ankle osteochondral lesions of talus / 中国医学影像技术

Objective: To explore the feasibility of T1ρ technique in evaluating ankle osteochondral lesions of talus (OLT). Methods: Totally 40 patients with ankle OLT underwent both conventional MRI and T1ρ imaging, also arthroscopy examination within 1 week. Conventional MRI,arthroscopy and T1ρ imaging were observed, and ankle OLT were classified into - type (type - injury group, respectively) according to the improved Hepple classification standards. Then normal cartilage areas of 20 cases were randomly selected as the normal control group. T1ρ values of cartilage in each group were measured and analyzed. The consistency of OLT typing Results: using conventional MRI and arthroscopy was compared. Results: T1ρ images could clearly show ankle talus cartilage, and the colorific orders were different according to the degree of injuries. T1ρ values of cartilage increased with the aggravation of cartilage damage. There was no statistically difference (P=0.12) in T1ρ values of damaged cartilage of type injury group ([43.07±2.05]ms) and type Ⅱ injury group ([45.24±2.19]ms), whereas statistically differences of T1ρ values of damaged cartilage were found among other groups (P<0.05). The consistency of OLT typing Results: using conventional MRI and arthroscopy was good (Kappa=0.80, P<0.01). Conclusion: T1ρ technique can clearly display the talus cartilage of the ankle joint and quantitatively evaluate the degree of talus cartilage damage, especially for patients with early talus cartilage damage.

Cartílago y gonartrosis / Cartilage and knee osteoarthritis

RESUMEN Fundamento: el cartílago articular es un tejido avascular, aneural y alinfático que desempeña un importante papel en la articulación, su afección más frecuente es la de tipo degenerativa. Objetivo: actualizar los conocimientos sobre el cartílago articular normal, envejecido y con cambios degenerativos. Métodos: la búsqueda y análisis de la información se realizó en un periodo de tres meses (primero de octubre al 31 de diciembre de 2018) y se emplearon las siguientes palabras: cartilage AND osteoarthritis, cartilage AND knee osteoarthritis, cartilage a partir de la información obtenida se realizó una revisión bibliográfica de un total de 164 artículos publicados en las bases de datos PubMed, Hinari, SciELO y Medline mediante el gestor de búsqueda y administrador de referencias EndNote, de ellos se utilizaron 50 citas seleccionadas para realizar la revisión, de ellas 48 de los últimos cinco años. Resultados: se mencionan los aspectos macro y microscópicos del tejido, así como su organización por zonas y áreas. Se describen los cambios que ocurren en el proceso degenerativo a diferentes niveles y en el envejecimiento. Conclusiones: el cartílago articular es la estructura anatómica más afectada en la articulación por el proceso degenerativo. Se encuentra organizado por zonas y áreas, las que se afectan a medida que avanza la enfermedad. El origen de la destrucción del cartílago es enzimático y repercute en las demás estructuras como el tejido sinovial y hueso subcondral. Es importante conocer las diferencias entre el envejecimiento y la afección degenerativa de este tejido.

ABSTRACT Background: articular cartilage is an important avascular, alinphatic and aneural tissue in joints, it is mainly affected by degenerative disease. Objective: to update knowledge about normal, aging and degenerative articular cartilage. Methods: a three months research and analysis were conducted from October 1st, 2018 to December 31th, 2018. Our review included 164 articles published in PubMed, Hinari, SciELO and Medline databases by using EndNote. The words used were cartilage AND osteoarthritis, cartilage AND knee osteoarthritis, cartilage. Fifty citations were selected, 48 of all them within the last five years, were used to write the present paper. Results: macro and microscopic features of articular cartilage were mentioned as well as its organization in zones and areas. Degenerative process was described at different levels, and in aging. Conclusions: articular cartilage is the most affected tissue in osteoarthritis. Cartilage is organized by zones and areas which are affected as degenerative disease progresses. The start point of osteoarthritis is enzymatic and gradually affects synovial tissue and sub-chondral bone. It is important to know the main differences between aging and degenerative cartilages.

Caracterización clínica, imagenológica y quirúrgica de la discopexia en pacientes con artropatía discal de la art iculación temporomandibular. Estudio de serie de casos / Clinical, imagenological and surgical characterization of discopexia in patients with discal arthropathy of the temporomandibular articulation. Case series study

Introducción: El desplazamiento discal es la artropatía temporomandibular más común. Los desplazamientos discales sin Reducción (DDSR) constituyen una condición clínica en la cual en boca cerrada el disco articular se encuentra desplazado completamente, sin contacto con la vertiente anterior de la cabeza mandibular y en boca abierta el disco no es recapturado. El tratamiento quirúrgico realizado es la discopexia. A pesar de toda la información presente en la bibliografía aún existe controversia entre la elección de tratamiento del DDSR. Objetivo: Presentar la experiencia clínica, quirúrgica e imagenológica de la discopexia en DDSR mediante la presentación de una serie de casos. Metodología: Se realizó un estudio retrospectivo de las historias clínicas del Servicio de Cirugía Bucal y Maxilofacial del hospital General del Oeste "Dr. José Gregorio Hernández", Distrito Capital, Venezuela, entre 2014-2018; se seleccionaron seis casos clínicos que presentaban DDSR, los cuales fueron intervenidos con discopexia, posteriormente se evaluaron clínica e imagenológicamente. Resultados: Los seis casos presentaron particularidades en el transcurso del tratamiento desde la fase inicial y en la postoperatoria. Se evidenció una franca mejoría en las manifestaciones clínicas, en contraste, la resonancia magnética postoperatoria, el cual reveló el desplazamiento discal nuevamente. Conclusiones: La estabilidad en la reubicación discal postoperatoria depende de múltiples factores, tales como la estabilidad oclusal, muscular y presencia de hábitos parafuncionales. El aumento en la apertura bucal fue la característica común en todos los pacientes de este estudio así como la disminución de la sintomatología dolorosa.

Introduction: Disc displacement is the most common temporomandibular arthropathy. The displacements without reduction (DDSR) become a clinical practice in the closed mouth the articular disc is completely displaced, without contact with the anterior vertical of the mandibular head and in the open mouth the disc is not recaptured. The surgical treatment performed is discopexy. Despite all the information present in the literature there is still controversy between the choice of treatment of the DDSR. Objective: To present the clinical, surgical and imaging experience of discopexy in DDSR by presenting a series of cases. Methodology: A retrospective study of the clinical records of the Oral and Maxillofacial Surgery Service of the General del Oeste Hospital "Dr. José Gregorio Hernández ", Capital District, Venezuela, between 2014-2018; Six clinical cases were selected that presented DDSR, which were operated on with discopexy, and then evaluated clinically and imaging. Results: The six cases present particularities in the course of the treatment from the initial phase and in the postoperative period. The evidence is improved in the clinical manifestations, in contrast, in the postoperative magnetic resonance, in the articular disc it moved again. Conclusions: Stability in postoperative disc relocation depends on multiple factors, such as occlusal stability, muscle stability and the presence of parafunctional habits. The increase in oral opening was the common feature in all the patients for this study, as well as the decrease in painful symptoms.

Retrospective study of radiographic changes in athletic bulls with orthopedic disorders / Estudo retrospectivo das alterações radiográficas de touros atletas com doenças ortopédicas

The objectives of this study were to demonstrate the lesions that affect athlete bulls and to correlate the disorders with weight, age, affected limb and region of the limb. The present study was accomplished using radiographic images of athletic rodeo bulls collected from the medical and surgical records of the large animal service at the veterinary hospital. Radiographic images were evaluated for 136 bulls that were taken care of at the Veterinary Hospital, ranging in age from 4 to 13 years, with an average weight of 800kg and proven prior physical activity through participation in rodeos. The chi-square or Fisher's exact test was used to assess the association between the studied variables. It was observed that 71.6% of the bulls studied and suffering from lameness had radiographic lesions, predominantly in experienced animals. Enthesopathy in starter and experienced bulls, septic arthritis in starter bulls, and fractures and degenerative joint disease in experienced bulls were the most frequent radiographic lesions diagnosed. The region of limb where the majority of radiographic changes occurred was the digits. Risk factors and occurrence of diseases of the locomotor system in athletic bulls are similar to those in sport equines.(AU)

O objetivo desse trabalho foi demostrar quais lesões acometem touros atletas, correlacionando as desordens com peso, idade, membro e região afetada. O presente estudo foi realizado utilizando radiografias de touros atletas de rodeio, após levantamento dos prontuários clínicos e cirúrgicos do serviço de grandes animais de um hospital veterinário. Foram avaliadas radiografias de 136 touros que haviam sido atendidos em tal hospital, com idade variando de quatro a 13 anos, com média de peso de 800kg e realizavam participação em rodeios. Para avaliar a associação entre as variáveis estudadas foi utilizado o teste exato de Fischer e o Qui-quadrado. Observou-se que 71,6% dos touros estudados que claudicavam, apresentavam lesões radiográficas, predominantemente em animais mais experientes. A entesiopatia em todos os animais, artrite séptica nos touros iniciantes, fraturas e doença articular degenerativa nos touros mais experientes, foram as alterações radiográficas mais frequentes. As regiões com maior ocorrência de lesões radiográficas foram os dígitos. Os fatores de risco para ocorrência de doenças no sistema locomotor de touros atletas são diversos, similares aos que ocorrem nos equinos atletas.(AU)

Evaluation of the ischiofemoral space: a case-control study / Avaliação do espaço isquiofemoral: um estudo caso-controle

Abstract Objective: To determine the size of the ischiofemoral space (IFS) and quadratus femoris space (QFS) in patients with and without ischiofemoral impingement (IFI). Materials and Methods: Case-control study including consecutive patients submitted to magnetic resonance imaging (MRI) of the hip joint during a three-month period. Patients with deep gluteal pain who tested positive for IFI on at least one clinical test and showed signal changes in the quadratus femoris muscle on MRI were categorized as having a confirmed diagnosis of IFI. Results: Final sample comprised 50 patients submitted to unilateral MRI of the hip joint. The mean age was 47.3 ± 14.0 years (range, 22-76 years), and 33 (66%) of the patients were women. A diagnosis of IFI was made in 6 patients (12%), all of whom were female. On average, IFS and QFS were significantly smaller in IFI group than in control group (11.1 ± 2.7 mm versus 27.5 ± 6.5 mm and 5.3 ± 1.8 mm versus 18.8 ± 4.8 mm, respectively; p < 0.001 for both). Conclusion: Results of specific clinical tests and MRI findings indicate that the IFS and QFS are significantly reduced in patients with IFI.

Resumo Objetivo: Avaliar, prospectivamente, os valores médios dos espaços isquiofemoral e quadrado femoral em pacientes com impacto isquiofemoral e em um grupo controle. Materiais e Métodos: Estudo prospectivo incluindo pacientes submetidos a ressonância magnética da articulação do quadril em um intervalo de três meses. Os pacientes com dor glútea profunda, com pelo menos um teste clínico positivo para impacto isquiofemoral e alterações de sinal no músculo quadrado femoral na ressonância magnética, foram diagnosticados com impacto isquiofemoral. Resultados: A amostra final consistiu de 50 pacientes submetidos a ressonância magnética unilateral da articulação do quadril. A idade média foi 47,3 ± 14,0 anos (intervalo de 22 a 76 anos) e 33 (66%) eram mulheres. O diagnóstico de impacto isquiofemoral foi observado em 6 (12%) pacientes, todas mulheres. Os pacientes com impacto isquiofemoral mostraram redução significativa nos espaços isquiofemoral e quadrado femoral quando comparados ao grupo controle: 11,1 ± 2,7 mm versus 27,5 ± 6,5 mm e 5,3 ± 1,8 mm versus 18,8 ± 4,8 mm, respectivamente (p < 0,001 para ambos os grupos). Conclusão: Os pacientes com diagnóstico de impacto isquiofemoral apresentaram redução significativa dos espaços isquiofemoral e quadrado femoral após análise prospectiva baseada em testes clínicos específicos e ressonância magnética.

Snapping scapula syndrome: pictorial essay / Síndrome da escápula em ressalto: ensaio iconográfico

Abstract Snapping scapula syndrome manifests as an audible or palpable crackling during the sliding movements of the scapula over the rib cage, often perceived during physical or professional activities. It can be caused by morphological alteration of the scapula and rib cage, by an imbalance in periscapular musculature forces (dyskinesia), or by neoplasia (bone tumors or soft tissue tumors). In this pictorial essay, we review the main causes of snapping scapula syndrome, exemplified by a collection of didactic cases.

Resumo A síndrome da escápula em ressalto manifesta-se como uma crepitação audível ou palpável durante os movimentos de deslizamento da escápula sobre o gradil costal. Frequentemente percebida em atividades físicas ou profissionais, as suas causas podem ter origem na alteração morfológica da escápula e gradil costal, no desequilíbrio de forças da musculatura periescapular (discinesia) ou ainda em tumores ósseos ou de partes moles. O presente estudo revisou de forma ilustrativa as principais causas da síndrome da escápula em ressalto, exemplificadas por meio de uma coletânea de casos didáticos.

Biologically Active Complex for the Functional Support of the Connective Tissues: Scientific Rationale, Clinical Evidence

The prescription composition and the technology of a new type of specialized product - biologically active additive BAAhave been scientifically grounded. The pharmacological properties and functional orientation of the active principles of theformulation components of the dietary supplements were studied, which made it possible to determine the quantitative andqualitative composition of the formulation which has a synergistic effect on metabolic processes in the presence ofdeforming osteoarthrosis: bamboo extract, glucosamine and chondroitin, aloe vera extracts, leaves and grape seeds, vitaminand mineral composition with green tea extract, and the antioxidant complex "Cifrol-5". A production technology providinghigh consumer performance for the developed product was approved. Clinical trials involving two groups of women aged44-49 with deforming osteoarthritis of the knee joints confirmed the functional properties of the complex. The first groupreceived the BAA, the second was a control group. Changes in the control indicators were registered after dietary therapyor in clinically significant periods of patient recovery. The control indicators were joint soreness, skin, hair, and nailcondition, and the recovery time of postoperative sutures. The complex application of diet therapy and the basic treatmentfor dystrophic joint diseases and the rehabilitation measures of the postoperative period were shown to be effective. Inpatients, joint pain and pain index decreased, the fragility of nails and hair was reduced, the microcirculation of the nail bedimproved, and the healing time of the surgical sutures decreased. The consistency of quality indicators and consumerperformance was ensured by production certifications for the developed products within the requirements of internationalstandards of the ISO 9001 and 22000 series and GMP rules.

Ochronotic arthritis:one case report and literature review / 中国基层医药

Objective To summarize the clinical manifestation,diagnosis and treatment methods of ochronotic joint disease,thus to improve grassroots medical workers awareness of ochronotic arthritis.Methods The clinical data of 1 case of ochronotic arthritis in the Second Municipal Hospital of Weihai Affiliated to Qingdao University and literature data were analyzed. Results The male patient,65 years old,because the right femoral neck fracture admitted to accidentally falls in patients with bilateral antihelix ear cartilage and local black pigmentation,resection of the femoral head cartilage surface,black,dark color round ligament,partial hip joint capsule was dark,multi segmental lumbar vertebral intervertebral space narrowing disc hardening,laboratory urine silver nitrate and ammonium hydroxide exami-nation appear dark brown discoloration, confirmed the diagnosis of patients with ochronotic joint disease. Conclusion We should improve cognition of ochronotic joint disease,examination by medical history,clinical mani-festations,laboratory and imaging,diagnosis of ochronotic arthritis,thus to reduce the rate of misdiagnosis.

Musculoskeletal Manifestation in Inflammatory Bowel Disease / 대한소화기학회지

Almost 50% of patients with inflammatory bowel disease (IBD) exhibit at least one extra-intestinal manifestation in their lifetime. Extra-intestinal manifestations of IBD are often associated with the intestinal disease activity, reducing the quality of life of the patient but rarely leading to fatal complications. Musculoskeletal involvement is the most frequent extra-intestinal manifestation of patients with IBD but this rarely occurs before IBD is diagnosed. They are manifested in various forms, such as arthropathy, fibromyalgia, and osteoporosis. Therefore, a multidisciplinary team approach including gastroenterologists and rheumatologists are necessary for optimal treatment. This review focuses on the diagnosis and treatment of musculoskeletal manifestations of IBD from the perspectives of rheumatologists who can assist gastroenterologists.